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Hypothetical compounds with different P-gp effects, peripheral compartment distribution kinetics, or times to achieve distribution equilibrium were simulated by perturbing the values of relevant model parameters.
(C) Cellular compartment distribution of 303 quantified proteins in our dataset.
The following blood compartment distribution of radioactivity was determined 5 min: 68 % blood cells, 2%% plasma proteins, and 30%% plasma supernatant; 30 min: 54 % blood cells, 4%% plasma proteins, and 42 % plasma supernatant; and 60 min: 43 % blood cells, 7%% plasma proteins, and 50%% plasma supernatant, respectively.
This analysis result is in accord with the above cellular compartment distribution, functional enrichment analysis.
The cellular compartment distribution tells how many proteins(and the percentage) in the datasets fall into each cellular compartment.
ATV is a substrate for P-glycoprotein (P-gp), an efflux transporter that will act to limit tissue compartment distribution.
Similar(25)
Many protein functions are currently deduced through comparative sequence homologies and theoretical prediction on the basis of cell compartment distributions.
One-, three-,hree-, and four-compartment distribution models were first evaluated during model building.
Piperaquine pharmacokinetics were described well by a three-compartment distribution model.
The pharmacokinetics of IM and desmethyl-IM have been described by a two-compartment distribution.
The data agree with a two-compartment distribution of ivermectin, with fat deposits acting as storage compartment.
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