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Next, we questioned which cell types are required for sensory progenitor proliferation and/or lateral compartment differentiation.
Upon every cell division, some progeny cells have to maintain the stem cell pool (self-renewal), whereas the others proceed to the next maturation compartment (differentiation).
See also Figure 4 figure supplements 1, 2. DOI: http://dx.doi.org/10.7554/eLife.05921.008 10.7554/eLiFigure21.009 Figure 4 figure supplement 1. Epithelial Fgfr1 is required for lateral compartment differentiation and HC and SC patterning.
These stages represent the key developmental events that are central to the endosperm's role as an absorptive structure, including early cell proliferation, compartment differentiation, initiation of starch and storage protein accumulation and rapid fresh weight increases [ 5],[ 23].
In the subsection headed " Fgf9 and Fgf20 regulate cochlear length and Fgf20, not Fgf9, is required for lateral compartment differentiation and patterning", when you state "…the normal pattern of three rows of OHCs…", there should be a reference to the later panels (C, D) here as well.
Together, these data, and those presented above, showed that epithelial Fgfr1, but not Fgfr2, is required for lateral compartment differentiation, and has a modest effect on cochlear duct length of a similar magnitude to the 10% reduction in cochlear length seen in Fgf20 lacZ/lacZ mice (Huh et al., 2012).
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Retrievable information include gene expression, signaling pathways, cell types, developmental stages, anatomical compartments, differentiation protocols, diseases, cell therapies, and literature references.
Repopulation of the original ductal compartment and differentiation into less primitive acinar cells was readily observed.
We conclude that Myc-induced chromatin modifications play a major role in Myc-induced exit from the stem cell compartment and differentiation into interfollicular epidermis and sebocytes.
Onset of Ngn3 expression represents the exit from the stem cell compartment toward differentiation.
This requires a complex balance between the proliferating compartment, the differentiation compartment and the cornified envelope, which exert its protective barrier function in the epidermis.
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