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These comparisons were tested using generalized estimating equations (GEE) implemented in the R based package APE [16], [17].
Multiple comparisons were tested using ANOVA plus post hoc Holm-Sidak and differences between groups tested via two-tailed Student's t-test.
Pair-wise comparisons were tested using a t-test.
All comparisons were tested for significance using Fisher's exact tests.
Intergroup comparisons were tested by the Mann-Whitney U test.
Post-hoc pairwise comparisons were tested using paired t-tests.
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Statistical significance of comparisons was tested by the Student's t test, using GraphPad Instat programs (GraphPad Software Inc., San Diego).
Significance of pairwise population comparisons was tested by 20,000 permutations.
Significance of the pairwise comparisons was tested with a 2 × 2 table.
The statistical significance of these comparisons was tested using a two-sample test of proportions in Stata version 9.2.
Statistical significance of group comparisons was tested with Student's t test or Mann-Whitney U test for simple intergenotype differences.
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