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Statistical comparisons were calculated by using Student's t test, p values of <0.05 was taken to indicate statistical difference.
P values for tumor growth were calculated by Kaplan-Meier Time to Progression method, and p values for two sample comparisons were calculated by two-sided Wilcoxon Rank-Sum test.
Statistical comparisons were calculated by Student's two-tailed t-test.
Two group comparisons were calculated by the Mann-Whitney U-test.
Pairwise R ST comparisons were calculated by using ANOVA (a nested analysis of variance approach).
Two group nonparametric comparisons were calculated by the Mann–Whitney U-test.
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Additionally, the actual effect size per comparison was calculated by using least square mean (LSM) duct lengths.
Pair wise group comparison was calculated by Tukey's multiple comparison test.
The relative fold change for each comparison was calculated by 2^-ΔΔCt.
Global methylation comparison was calculated by averaging 1kb window methylation levels of CpGs covered by at least 30 reads.
A baseline for comparison was calculated by dividing the total number of measurements across the whole data set from patients with a particular outcome by the total number of data points.
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