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The program was run on the gap-free concatenated alignment of the 13 protein-coding genes, with codon frequencies calculated from the average nucleotide frequencies at the three codon positions (option CodonFreq = 2), and maximum likelihood (ML) estimations in pairwise comparisons (option RunMode = -2).
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Furthermore, the Sidak's posthoc test was chosen because it provides an optimised balance between Type I and Type II errors compared to the two other tests available under the pairwise comparisons options in SPSS- the Least Significant Difference (LSD) Test (equivalent to an uncorrected t-test) with a high Type I error chances and Bonferroni's test with low power and high Type II error chances.
Each pathway and reaction details page also provides a cross-species comparison option to compare details of the specific pathway or reaction between any two or more species (Figure 2A).
The SAMMD help page shows an illustration of the dataset comparison option.
The Holm-Sidak pairwise-comparison option was adopted to obtain t-test scores.
Most statistical packages include this comparison option among the output options for the general linear model or ANCOVA.
The best fit model was determined by the "Model Comparison" option and confirmed by other additional options of WinModest software.
Only Amara et al. [ 20] used the typology approach, and this study seems our only comparison option.
Other ways in which evidence can be indirect include differences between a study and the setting of interest in: The characteristics of the population The option being considered, or The status quo or comparison option Studies that find statistically significant effects are often more likely to be published than those that do not [ 16].
Gene sets were retrieved directly from Ensembl database using the multi-species comparison options in the BioMart web interface [ 47].
In table 4, an overview of comparison options by healthcare services and indicators of migrant background is given.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com