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* P value for comparison with premenopausal women.
The postmenopausal women had significantly higher age, A-FABP, SBP, DBP, glucose, TG, TC, LDL-C, TC/HDL-C ratio, FSH, leptin, and 10-year ASCVD risk and significantly lower E2 and DHEAS in comparison with premenopausal women.
In comparison with premenopausal women who had a low BMI (less than 25 kg/m), the OR among premenopausal women in the highest BMI category (at least 35 kg/m) was 0.58 (95% CI 0.34 to 1.00) for ER+PR+ breast cancer and 1.07 (95% CI 0.58 to 1.97) for ER- PR- breast cancer.
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A comparison of premenopausal women with age-matched men showed that phosphatidylserine and P-selectin positive MV were higher in women whereas there were no statistically significant differences in tissue factor, tissue factor pathway inhibitor, and cellular adhesion molecules (ICAM-1 and VCAM-1) positive MV population (Table 2).
The statistically significant higher levels of discrimination of Mets, HOMA-IR ≥ 3.4, TC/HDL-C ≥ 4, and hypertension were found for A-FABP in premenopausal women in comparison with postmenopausal women.
We did not find any correlation between the presence of cancer cells and recurrence or any other clinical prognostic factors except one: patients with premenopausal status had cancer cells in the blood in 37% of cases, in comparison with those with postmenopausal status who had cancer cells in 63% of cases.
compared with premenopausal women.
We provide suggestive evidence of a role for premenopausal estrogens and androgens in postmenopausal disease, with premenopausal estrogens inversely and premenopausal androgens positively associated with postmenopausal breast cancer.
These associations were stronger among postmenopausal compared with premenopausal women.
However, another study reported no association with premenopausal BC [ 54].
There was also slight increase in levels of leptin, visfatin, and resistin in premenopausal BC cases in comparison to premenopausal controls.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com