The results show an average SRI yield of 9.5 t/ha, compared with 4.93 t/ha in the comparison trials with usual methods, a 93% increase.
Monthly oral ibandronate, the first approved monthly bisphosphonate regimen, was supported by comparison trials with the daily regimen and has been in use since 2005 (Miller et al 2005; Reginster et al 2006).
In only two cases (adalimumab and ustekinumab) did all three agencies clearly report considering an identical set of direct comparison trials, with adalimumab being recommended for reimbursement by two of the agencies, and ustekinumab by all three.
It seems important to conduct head-to-head comparison trials with these agents in the future and also to determine if linaclotide is more efficacious in certain constipated individuals than are currently available laxatives.
Design: Randomized controlled-comparison trial with 3 parallel groups.
An assessor-masked, block randomised comparison trial will be conducted with random allocation to either group-based or individual physiotherapy.
Using a reasonable population estimate of 11% for a primary composite endpoint of perinatal death or morbidity for women randomised to the ursodeoxycholic acid comparison, a trial with reasonable power to detect a plausible effect size can be designed.
The MedLey study is a 6-month, randomised, controlled, 2-cohort parallel group comparison intervention trial, with repeated measures every three months, over three time points, to assess the effects of a MedDiet pattern with a habitual Western dietary pattern on age-related cognitive performance and cardiometabolic health.
For example, Merz Pharmaceuticals, which makes the popular product Mederma, says it is "clinically proven to improve the softness, texture and overall appearance of scars". But there were just two randomized comparison trials of Mederma, with a combined total of 38 participants.
