As the objective of this analysis is to compare the utilization of pregabalin and venlafaxine XR in the management of patients with generalized anxiety disorder, clinical data was obtained on a single direct comparison clinical trial between these two drugs.
The model uses clinical data from an 8-week flexible dose direct comparison clinical trial between the two drugs; utility values based on a Spanish study; and Portuguese economic data, being the resource consumption obtained via an expert panel.
Such disease heterogeneity makes comparison of trials between geographic regions and with differing composition of diseases (gallbladder, intra- and extrahepatic tumours) challenging.
Still, we believe the comparison within each trial between groups of higher and lower Hb levels, whether by a definite transfusion trigger or by observed exposure to different Hb levels, is valid.
Quantitative positron emission tomography (PET) imaging, and 18F-fluordeoxyglucose (FDG) in particular, has emerged as a useful tool for comparison between trial outcomes and better response monitoring [1].
There is no standard definition of 'postmenopausal' to enable the comparison of between-trial results, and estrogen levels were not repeatedly measured in the majority of BC clinical trials.
To address this situation and to allow comparison between trials a panel of experts working in DC-based clinical trials in HIV-1 infection met in Barcelona at the end of 2010.
Adverse events recorded in the clinical trials in SLE have not been adequately standardised to allow comparison between trials.
However, the trials had important differences in terms of design, populations studied, and statistical analysis that preclude comparison between trials and should be considered when interpreting findings.
The use of the catalytic bed reactor has given the possibility to perform the transesterification maintaining the catalyst separated from the reactants, without loss of efficiency; in fact the comparison between trials in batch reactor and in catalytic bed system has not shown differences in yields.
However, comparison between trials is clearly flawed given differences in the populations studied and in particular the lack of comprehensive genotype-specific outcomes.
