Exact(1)
Of the 41 CpGs interrogated in the region of the APOE gene by the Illumina beadset, the level of methylation of eight CpGs is significantly associated with the APOE ε4 haplotype (P-values between 0.006 and 5.1 × 10−11); however, none of those CpGs met the multiple comparison threshold for association with NP burden, although four displayed suggestive evidence of association (P < 0.05) (Table 3).
Similar(7)
* Denotes significance at the α = 0.05 level after Bonferroni correction for multiple-comparisons (threshold for significance is p = 0.05/8).
Monte Carlo simulation was implemented to correct for multiple comparisons (threshold of 53 contiguous voxels with a z-value ≥ 2.25).
In comparison the threshold for WIC in the US is more generous and increases according to family size [ 50].
In the case of the RDEB/healthy comparison the threshold for significance was set at a two-fold down- or up-regulation.
To account for multiple comparisons the threshold for significance was p < 0.003.
For all comparisons, the threshold for significance was set at 0.01.
This offers a possibility for the comparison of thresholds for biomarkers of exposure versus biomarkers of effect.
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