Based on the comparison of the expression of total MTP and MTP-B mRNA in wild-type and MTP-A deficient mice, it can be estimated that ∼35% of the total amount of MTP mRNA represents the MTP-B transcript and ∼65% represents the MTP-A transcript in the mouse heart.
Based on a comparison of the expression of the activated and the repressed targets of a regulator, the influence is computed in a sample-specific manner (details in Supplementary Information).
Given the opposing effect of conjugated and unconjugated neurosteroids on neurotransmitter signaling the comparison of the expression of the e.g. GABAA signaling cascade components before and after treatment would have been of interest.
Comparison of the expression of all genes on the microarray to expression of genes bound by CTCF or CTCFL revealed that the CTCFL-bound genes were, on average, more abundantly expressed.
In comparison, the expression of both genes peaked on day 5 in the attachment culture technique.
The chronological comparison of the effects of RANKL stimulation on the expression of the cluster 65 genes revealed that although stromal cells beneath the FAE express high levels of RANKL, not all of the FAE-related genes identified in this study are directly induced by RANKL stimulation.
This conclusion is based on the comparison of Aberration:wild type expression ratios to diploid expression ratios and is, therefore, dependent on the assumption that chromosomal aberrations as such have no effect on the expression of diploid genes.
Our approach was based on the comparison of the expression profiles of pairs of probes using Pearsons correlation coefficients which were used to create a network linking genes together on the basis of their shared expression properties.
Prior to the gene expression analysis, the samples were paired in a dendrogram based on a comparison of the expression profiles of all the genes.
In an attempt to better understand the effects of exposure on development and to predict the amount of developmental delay, we developed a linear regression-based method for computing a Predicted Age (PA) for comparison purposes based on the expression level of developmentally-regulated genes and the time of harvest (see Methods).
