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Additionally the heterogeneity of the included studies design and size made evaluation and comparison of trials difficult.
Our contention is that the comparison of trials containing threat stimuli to trials that do not include threat stimuli is a relatively untapped resource [24], [41] for understanding how the mere presence of threat may influence behavior.
Such disease heterogeneity makes comparison of trials between geographic regions and with differing composition of diseases (gallbladder, intra- and extrahepatic tumours) challenging.
The phenotypic and functional heterogeneity of MSC preparations from different laboratories has rendered a proper comparison of trials from different institutions impossible.
Trials were classified according to their funding source(s) in a manner similar to that used by Rochon [ 17], permitting comparison of trials across four levels of funding: entirely industry, entirely not-for-profit, mixed and not reported.
Secondly, it enables comparison of trials that use a similar approach with one another, rather than putting all acupuncture trials together as if they were all the same (that is, comparing like with like), both in discussions of the implications of a single trial in relation to others and within a systematic review.
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In the 1990s, techniques such as meta-analysis – using statistical methods to analyse and integrate the results of different studies – allowed rigorous comparison of trial results.
Results from the burden analysis presented here should be interpreted cautiously in light of the lack of country-specific norms used for comparison of trial patients' SF-12v2 scores, and future research should address this issue.
Also, to allow for comparison of trial outcomes and an international collaboration on drug development and therapy for migraine, there must, at least to some extent, be a global agreement on trial design and the parameters used for the assessment of efficacy, adverse events and safety.
In our review, only 11 reviews (26%) undertook some kind of comparison of trial or patient characteristics.
Again, the significant interaction was followed up by a comparison of Trial Types within each Block.
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