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Pairwise comparison of sequence data is intensively used for automated functional protein annotation, while graphical models emerge as promising candidates for an integration of various heterogeneous features.
Pan-genomic reverse vaccinology, with the comparison of sequence data from multiple isolates of the same species of a pathogen, increases the opportunity of the identification of novel vaccine candidates.
Comparison of sequence with known cis-regulatory motifs disclosed a number of potential regulatory elements including an octamer binding motif at -76, Sp1-binding sites at -94 and -63, E boxes at -110, -26, and +18, an AP-1 site at -442, and an AP-2 site at -330.
Comparison of sequence conservation among these 15 mammals, revealed a linear pattern of change relative to these four exons during the course of mammalian evolution.
FUGUE produces alignments by comparison of sequence profiles with structural profiles of homologous protein families taken from the HOMSTRAD database [32].
Comparison of sequence alignments showed cyt b as more variable for both inter- and intraspecific comparisons, which is in line with previous studies [31].
The program aligns and scores (percent sequence similarity) sequences facilitating base by base comparison of replicate samples as well as comparison of sequence samples against an established standard.
Our sequence analysis was performed on clonal HIV-1 variants isolated from single productively infected cells as this allows the comparison of sequence dynamics in different genes of a single virus variant.
Comparison of sequence information to publicly available DNA information was performed using BLAST [ 58].
10.7554/eLife.00306.009 Figure 4. Comparison of sequence conservation between individual protein clusters.
Comparison of sequence identity between orthologous rayt genes revealed an interesting phenomenon.
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