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A helpful feature is side-by-side comparison of guidelines.
Moreover, it simplifies the comparison of guidelines for the same clinical conditions.
This paper reports on a protocol designed to enable thorough and systematic comparison of guidelines and guidance documents on palliative sedation.
To the best of our knowledge, this is the first study protocol for a systematic comparison of guidelines and guidance documents on palliative sedation.
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A comparison of these guidelines found that treatment volumes differed significantly between guidelines and that the European Organisation for Research and Treatment of Cancer (EORTC) volume was significantly smaller than the other guideline-produced target volumes.
The protocol is applicable to all guidelines on palliative sedation, and the approach will contribute to rigorous and systematic comparison of international guidelines on any challenging topic such as this.
Comparison of the guidelines from the International Association for the Study of Pain Neuropathic Pain Special Interest Group, European Federation for Neurological Societies, and Canadian Pain Society found a consensus for the use of TCAs, gabapentin, and pregabalin as first-line treatments for neuropathic pain [ 31].
An example is a comparison of mailed guidelines with and without an educational outreach visit from community pharmacists to improve prescribing in general practice.[ 2] If target differences for both interventions are identical, these would require increases in sample size of 50% and 100% respectively compared with a two-arm trial.
Table 4 shows a comparison of the guideline programs based on the six elements of the development process.
Our study approach included both qualitative descriptions [ 10] and comparisons of selected guidelines.
The authors have not performed a comparison of the two guidelines in ability to predict mortality as firstly, the sample size is too small and secondly the impetus was to focus on how diastolic dysfunction is defined in this cohort, something which is a significant limitation of previous research.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com