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We note that the large, ineligible, last-release historical study in North Carolina, 1980 2005 [ 24] yielded a low relative risk comparing weeks 1 + 2 with weeks 3 12, 3.1 (95% CI: 1.7 5.5).
Test-retest reliability of the GIPD total score was checked by comparing weeks 6 and 8 in terms of Spearman's correlation coefficient for the items and Pearson's correlation coefficient for the total score for each perspective.
A three- to eightfold increased risk of drug-related death was found when comparing weeks 1 + 2 with weeks 3 12, with notable heterogeneity between countries: United Kingdom, 7.5 (95% CI: 5.7 9.9); Australia, 4.0 (95% CI: 3.4 4.8); Washington State, USA, 8.4 (95% CI: 5.0 14.2) and New Mexico State, USA, 3.1 (95% CI: 1.3 7.1).
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Comparing week 0 and 4 there was no significance found (p > 0.14).
The conventional group showed significant differences comparing week 0 and 4 (p = 0.04) and week 0 and 8 (p = 0.03).
Within the angular-stable group there was a significant increase of stiffness comparing week 0 and 6 (p = 0.024) and week 0 and 8 (p = 0.021).
Temporal CV R values were similarly calculated by first averaging weekly predictions across locations (one mean per week) and then comparing week-specific average measurements and predictions.
Within the angular-stable group there was a significant difference comparing week 0 and 6 (p = 0.021) and week 0 and 8 (p = 0.013).
Assessments compared weeks 9 12 to baseline.
For outcomes which failed the normality test (e.g. BODE score), Wilcoxon signed ranks test is applied to compare week 26 (week 14/ week 2) to baseline for the two arms, respectively.
For normally distributed outcomes (e.g. CCQ and SGRQ scores), paired t-test was applied to compare week 26 (week 14/ week 2) to baseline for the two arms, respectively.
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