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We find evidence for this inadequacy by comparing the alignment summary statistics for B6 and CAST liver samples aligned to their respective strain-specific transcriptomes.
In addition, we identified novel candidate genes or exons by comparing the alignment of the Arabidopsis transcriptome and gene predictions to those reads which aligned to unannotated regions of the genome.
To measure the two effects, Gravity Probe B tracked the motion of four gyroscopes, comparing the alignment of their axes of rotation with the direction to a reference star.
Paralogs are ruled out by comparing the alignment and read coverage of cSNPs relative to other SNPs.
8 The E value is the expected number of high scoring pairs for a certain nominated score when comparing the alignment of local pairs.
Empirical p-values for the SigB HMM alignments were determined by comparing the alignment score to the background scores using a Perl script and R-2.13.0 R-2.13.0
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While the number of new methods is estimated to be doubling roughly every five years (Hasegawa and Holm, 2009), several comparative studies have observed many inconsistencies and paradoxes when comparing the alignments generated by existing methods.
For example, when comparing the alignments of two related receptor subtypes that bind two different ligands, Spial allows the identification of residues that are specific to the binding of each of the ligands.
A SNP index largely composed of differences between homeologous loci was created by comparing the alignments of reads from A- and D-genome diploid species (A2 and D5, respectively) to the D5-genome reference.
To evaluate application-specific alignment features, at the beginning, we performed literature searching to grasp and compare the alignment algorithms of 19 favorable aligners.
Table 2 (middle) compares the alignment statistics of the three tools: LSC (full or trim) aligns less bases with less identities than LoRDEC.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com