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The values in this table are descriptive, not for comparing between groups.
Therefore, the analysis had to take into account such imbalance and this was the main reason why the effect of the intervention was estimated with an indirect rather than a direct approach, i.e. by comparing between groups, the rate of decrease over the 2-year follow-up period.
However changes in cardiopulmonary function were not as relevant when comparing between groups.
Growth hormone did not change significantly within groups during freely feeding, starvation and refeeding and it was not significantly altered when comparing between groups.
14 We used a limited dataset of questions and information on participant characteristics to minimize the effects of multiple testing when comparing between groups.
Further, for comparing between groups on neuropsychological measures, we performed a series of analysis of variance (ANOVA) with Bonferroni corrected post hoc comparisons, whenever main analyses reached significance.
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Univariate mixed model regression analyses compared between-group volume differences.
We also compared between-group differences in secondary outcomes.
An interim analysis comparing between-groups weight loss was conducted with 150 participants (4 more were in progress at the time), which resulted in early stopping of the trial due to clear evidence of efficacy.
Trends were compared between groups.
Levels of every parameter compared between groups.
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