For this differentiation, accuracy rates ranging between 84 and 89% are still in need of improvement, especially due to a substantially lower sensitivity compared with specificity of actual methods [10],[12],[15].
However, specificity was 79.6%, which is not significant when compared with specificity of spleen (Table 4).
However, the forest plot shows greater heterogeneity for sensitivity compared with specificity.
In considering the corresponding region of the ROC curve with sensitivity >0.9, while both the haplotype risk model and the GRS14 model had overall slightly higher specificity than the zygosity status, the greatest increase in specificity was observed for the GRS-DQ2.5 and GRS-DQ2.5-imputed models (specificity of 0.29 and 0.32, respectively, compared with specificity = 0.15 for the GRS14).
We argue that IgA levels above 24 U/ml and IgG levels above 27 U/ml decreased the specificities obtained in the internal controls, compared with the specificities obtained in the external controls.
However, the use of the relative threshold algorithm for the analysis of the data for the QVK duplex qPCR reduced the specificity of the assay from 100% to 43.47%, compared with the specificities obtained using the cycle threshold algorithm.
RBC antigen profiles of children and donors will be compared with antibody specificities that disappeared or persisted to determine whether the IUT donor and/or the fetus provided the offending antigens.
As for prediction of death after admission, the specificity of the ML score (73.9) was higher compared with the specificity of the MEWS (55.7) (difference in specificity: 18.2; 95% CI: 14.3 to 22.2).
In a prospective study by Fong, the combination of transvaginal ultrasound and hysterosonography for diagnosing endometrial abnormalities increased the specificity to 77.1% compared with a specificity of 55.7% with ultrasound alone[ 63, 67 ].
