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** p < 0.01, ***p < 0.001 for MPTP compared with Saline group, ###p<0.001 for Nil + MPTP compared with MPTP group.
Compared with saline group, the inhibitory rates of DPM@PL against tumor volume and lung metastasis were about 81% and 92%, respectively, and it didn't produce the significant systemic toxicity.
However, the changes did not reach statistical difference when compared with saline group.
The results were compared with saline group using unpaired Student's t test.
In parallel, there was also a remarkable increase in lung wet/dry ratio in LPS-challenged pigs compared with saline group (Fig. 1h).
Data are presented as means ± standard deviations, n = 5. *P < 0.01 compared with saline group; #P < 0.01 compared with lower dose carbon dot-treated group.
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However, the higher nano-SiO2 exposure groups (both OVA groups and saline groups) appear to have more severe inflammation (inflammatory cell influx) than the lower groups, and generally more serious inflammation is found in the OVA groups compared with saline groups.
A decrease of IL-6 plasma levels was found in all prednisolone groups compared with saline treated group (IL-6: saline, 192 ± 146.3 pg/mL; 5 mg/Kg prednisolone group, 21.33 ± 7.68 pg/mL; 12.5 mg/Kg prednisolone group, 33.63 ± 36.68 pg/mL; and 22.5 mg/Kg prednisolone group, 10.57 ± 9.79 pg/mL).
But for lower dosage (35 mg/kg) group, there was no significant changes compared with saline treated group.
At day 7, both silica-treated and Treg-depleted group showed higher level of IL-2 expression compared with saline control group (Fig. 5A).
Compared with saline treated group, the thrombotic wet weight decreased 33% and 42% after treated with ALA or its mixture group, respectively.
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