Industry sponsored trials more often planned subgroup analyses compared with investigator sponsored trials (195/551 (35.4%) v 57/343 (16.6%), P<0.001).
Compared with investigator chart review (our reference standard), we found that computer algorithms that used electronic clinical data outperformed manual review by infection control professionals.
Moreover, a randomized phase II trial with pembrolizumab at two different dosages (2 mg/kg or 10mg/kgg every three weeks) in advanced melanoma refractory to previous ipilimumab therapy showed that both doses improved PFS compared with investigator choice chemotherapy (Ribas et al., 2014).
In a separate phase III trial, nivolumab was compared with investigator's choice chemotherapy in patients who had experienced progression on ipilimumab and resulted in an increased overall response rate from 11%to32%2%, with less frequent high-grade adverse events (Weber et al, 2014).
In contrast, we found lower p-AKT and p-ERK expression when compared with other investigators (Blackhall et al, 2003).
In addition, because female patients have a better outcome when compared with males, investigators have explored the role of hormonal therapy for patients with advanced melanoma [20], [21].
In this section, various tools that support criminal network investigation are compared with CrimeFighter Investigator.
These classifications were compared with the investigator's using a weighted kappa statistic with quadratic weighting [ 20].
51, 52 The predictive value of clinical diagnosis of tumor non-clearance was 39% by the investigators, but when clinical diagnosis of positive clearance was compared with histology results investigators were correct in 100% of cases.
Overall, isotretinoin 0.3 mg/kg showed statistically significant noninferiority when compared with doxycycline therapy, with investigators documenting complete remission in 24% of patients treated with isotretinoin 0.3 mg/kg compared with 13.6% of patients treated with doxycycline.
