Five-year risk was computed by the cumulative incidence method and compared with hazards ratios (HR) from a Cox proportional hazards regression model adjusting for propensity score.
Compared with the hazard log generated by Hazard and Operability (HAZOP), the hazard log generated by BFM-STPA covered not only the subsystem failures, but also the deviation of interactions among subsystems from design intent, human errors and socio-technical drawbacks related to the TSR Issued scenario of CTCS-3.
New data from the study by Todo and co-workers supports these findings where the presence of para-aortic nodal metastasis has the most impact on prognosis (hazard ratio of 3.07 compared with a hazard ratio of 1.81 for age over 56 years and a hazard ratio of 1.87 for Grade 3 or non-endometriod histology) [8].
The ratio of positive lymph nodes as a continuous variable had the highest hazard ratio of 4.22, P<0.001, compared with the hazard ratio for the location of positive nodes (1.49) and number of positive nodes (1.05).
After exclusion of these other cases, the adjusted hazard ratio was 2.87 (1.97 to 4.18), compared with adjusted hazard ratio for the total cohort of 2.71 (1.86 to 3.95).
Each 1 mmol/L lower value of total BC was associated with a hazard ratio of 0.44 at ages 40 49 years compared with a hazard ratio of only 0.83 at the ages of 70 89 years (42).
Landman and colleagues have reported that patients with diabetes evidencing poor glycemic control (HbA1C > 9%) exhibited a hazard ratio of 2.21 for total mortality, compared with a hazard ratio of 1.0 among the control group with normal glycemic control levels (HbA1C < 6.5%).
Letrozole was particularly effective in decreasing the risk of distant recurrence by 27% compared with tamoxifen (hazard ratio 0.73; 95% CI 0.60 0.88; P = 0.001) (see Fig. 4).
In the safety on-treatment analysis (SOT), rivaroxaban demonstrated a 21% relative risk reduction for stroke and SE compared with warfarin (hazard ratio 0.79, 95% confidence interval [CI] 0.65 0.95, p = 0.02 for superiority test) [ 15].
In particular, a non-parametric estimate of the hazard function was calculated for the present data set and the result was compared with the hazard function that is assumed in the parametric Weibull model.
