With the apparent constancy of smoke exposure in CRS compared with controls, further studies are required to address the ramifications of exposure on disease pathology.
To confirm HER2 specificity of 64Cu-DOTA-trastuzumab PET imaging in humans, more cases of both HER2-positive and HER2-negative tumors are required, along with further study comparing the results of PET imaging with HER2 status.
Authors' conclusions Artesunate-pyronaridine performed well compared to the other two ACT with which it has been compared, but further studies in African and Asian children are required to help clarify whether this combination is an option for first-line treatment.
Subtype D is associated with faster progression to AIDS ([5], reviewed in [6,7]), more profound loss of CD4+ T cells [5,8] and decreased frequency of invariant natural killer T cells [9], as compared with subtype A. Further studies of subtype D infection are warranted to understand subtype-dependent differences in HIV-1 immunopathogenesis.
Since either cells that are dead or undergoing apoptosis, like cells that are stuck in G0/G1, may also show reduced [H]-thymidine incorporation compared with control cells, further studies are necessary to clarify what the relative contributions of apoptosis vs. reduced proliferation are to the growth inhibition observed in the lung cancer cells.
However, the UPLIFT-cohort had a lower baseline mean FEV1 compared with our study, further, as most clinical studies the UPLIFT-study included a selected population with regard not only to lung function but also to other factors such as age and co-morbidity.
Hence, it will be interesting to investigate and compare in further studies with animal models the efficacy of inactivated and live-attenuated vaccines to provide protection against infection with the pandemic (H1N1) 2009 virus.
Randomized controlled trials suggest clinical outcomes may be improved with dexmedetomidine as compared with benzodiazepines; however, further study and validation are needed.
The respective contributions of biology, disease severity and social factors on the risk of disability among women as compared with men needs further study.
