In our design, we treated the global stimulus 'ba-bi-bu-be' as the standard to be compared with deviants differing on one syllable.
For the primary end point of cardiovascular death, major coronary event, or nonfatal stroke, the relative risk reduction of combination therapy compared with monotherapy differed by eGFR (P=0.04).
The percentage change in ApoB at week 4 compared with baseline differed significantly between treatment groups (p 0.007).
However, the results for denosumab compared with alendronate differed, with ICERs ranging from €25,046 to €98,776 for patients younger than 75 years and with no previous fracture, and from €6,918 to €35,427 for patients younger than 75 years with a previous fracture.
Furthermore, although the TEQ system is useful when comparing samples with differing congener profiles, it is somewhat limited in that any differences in uptake or behavior of individual congeners is not taken into account.
Before comparing patients with differing clinical responses, a hierarchical clustering was performed on the 876 genes that had M values (sample versus universal RNA reference) with interquartile ranges > 1 in the first series of hybridizations.
Responsiveness provides the basis for comparing measures with differing scales and can be measured using variables such as effect size [ 3], standardized response mean [ 4], and relative efficiency [ 5].
It could be argued that it is not appropriate to directly compare studies with differing methodologies, or include studies that have a very wide range of interventions (eg, those that include physical and social as well as cognitive elements), due to the inability to isolate the active ingredient in these regimes.
Finally, it is also important to mention that only one study included children only, and thus, we are unable to determine if the effect of mould-active prophylaxis compared with fluconazole differs between children and adults.
Several of these studies have compared procedures, often with differing conclusions.
