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bbg RNAi border cell clusters contain a similar number of cells compared with control clusters.
33 Moreover, indoor density of P argentipes was reduced by 25% in the study clusters that used treated nets compared with control clusters.
Coefficients less than 1 are associated with a less favourable response for that demographic subgroup of women in the intervention compared with control clusters.
For the principal analysis of primary outcomes we used an unpaired t-test of vaccination rates children aged 12-23 months in intervention clusters compared with control clusters.
The intervention clusters were slightly disadvantaged compared with control clusters, with less access to primary health centres and fewer community health workers such as Anganwadi workers or Auxiliary Nurse Midwives.
At cluster level, the risk of infection was reduced by 10% in the intervention clusters compared with control clusters, but this effect was not significant (risk ratio 0.90, 95% confidence interval 0.49 to 1.65).
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On multivariable analysis, compared with control, cluster headache was significantly associated with GAD-7 (beta 4.4; 95% confidence interval 2.7 to 6.0; p value < 0.001) and PHQ-9 (3.9; 2.1 to 5.6; <0.001).
A restricted number of genes showed either impaired variation when compared with control cells (clusters b and d) or variation restricted to cells with low levels of HP1γ (Figure 5B, cluster e), but their analysis did not reveal any convergent function.
To visualize gene expression changes between treatments and sensitized compared with control dogs, hierarchical cluster analysis (HCL) and clustering of similar expression profiles over time [self-organizing tree algorithm (SOTA) analysis] were performed based on expression values relative to the mean expression value of all samples for each gene, respectively.
Results There was no significant difference in the risk of seroconversion over 24 months in intervention (5.4%; 347/6372) compared with control (5.5%; 345/6319 people) clusters (risk ratio 0.90, 95% confidence interval 0.49 to 1.65) nor in the risk of clinical visceral leishmaniasis (0.99, 0.46 to 1.40).
This revealed that microtubule depletion significantly reduced jasplakinolide-triggered clustering compared with control cells (mean PDD; Noc/JK = 17.86 ± 1.908 μm versus DMSO/JK = 14.16 ± 2.034 μm; Figures 2Ai and 2Aii).
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