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The proposed combination of five quality features has the best correlation with the MOS, which were compared using either SROCC or PLCC.

Statistical significance between the means was compared using either Student's t-test or single factor ANOVA.

Weight loss, Colon length, IBD Scoring and cellular distributions were compared using either Student t-test or ANOVA test.

Results of experimental groups were compared using either a two-tailed Student's paired t-test or nonparametric Mann-Whitney t test using Prism software (GraphPad software, SanDiego, CA).

Based on normality, group means or medians were compared using either a Student's t-test or Wilcoxon Rank Sum test; a p-value of 0.05 was considered nominally significant.

The number of human lamin A/C+ nuclei, human spectrin+ fibres, human spectrin+ fibres containing human lamin A/C+ nuclei and the number of human lamin A/C+ nuclei inside or outside basal lamina were counted using MetaMorph software and compared using either Student's t test or one-way ANOVA.

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Data from comparative groups in the in vivo study and the in vitro drug combination work was compared using ANOVA (either two way or two way repeated measures, as appropriate) in the Graphpad Prism software package.

Data are compared using with either the Student's (two-tailed) t-test or a one way ANOVA and P<0.05 is considered significant.

Matched groups of control and test data were either compared using an independent t-test (intracellular Ca2+ measurement) or paired t-test (electrophysiology performed on the same cell).

The substrate specificities of the shrimp nuclease, the crab nuclease [14] and DNase I was compared using this substrate, either as ssDNA (first strand only) or as dsDNA (first and complementary strand).

Multiple regimens have been compared, using a platinum, either carboplatin or cisplatin, as one agent in combination with another cytotoxic agent.

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