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We found that 26% of reviews compared trial and patient characteristics across all the trials used in the indirect comparison; Song et al stated that 30% of reviews compared characteristics.
This was a prospective cohort study, with a historic group compared trial set in an urban emergency medical services system, serving a population of 200,000.
We compared trial participants with the children who were eligible for enrolment, but were travelling during the campaign or not participating for other reasons.
We compared trial protocols with subsequent reports, and then conducted interviews by telephone with the trialists to obtain information relating to discrepancies.
A trial that is stopped prematurely with an effect that is significant (e.g., P < 5%) may reach this significance level because the estimated difference in effect between the compared trial interventions is larger than anticipated or because the estimated variance is lower than anticipated — or both (see Section 2 about sample size estimation) [ 27, 29, 33].
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Researchers compared trials of homeopathic and conventional medicines.
Eleven reviews compared trial-level characteristics.
We compared trials in which rules were selected with trials in which actions were selected.
Few studies have empirically compared trials reporting surrogate and final primary outcomes.
Comparing trial types to baseline in each task revealed widespread activation for single, stay, and switch trials in both color-shape and language switching.
In order to establish causality, further research would first be required to compare trial reporting with actual trial conduct and then to compare these findings across locations.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com