Longstanding ulcerative and Crohn's colitis increases the risk of colorectal cancer (CRC) compared to the general population.
Furthermore, UC is associated with a markedly increased risk of developing CRC compared to the general population, which depends on both the duration and extent of disease, and may reach 7.6%% of patients with extensive longstanding UC.
This issue has been highlighted recently as new work has revealed striking differences between the time-domain noise sensitivity of control protocols as compared to longstanding notions of error cancellation in the Magnus expansion [37, 38].
We hypothesized that patients with suspected early AS may demonstrate a similar pattern of abnormalities compared to patients with longstanding and confirmed AS.
In the East Midlands, only 9% of those with a limiting, longstanding illness reported taking regular exercise compared to 23% of those without longstanding health problems [ 4].
We recently detected highly expanded T cell clones in the synovium of patients with early RA as compared to that of patients with longstanding RA (30), suggesting that T cell involvement has a role in the early phase of the disease.
We have confirmed that mean telomere length is reduced in dysplastic colonic mucosa in progressor colons of longstanding UC compared to non-dysplastic mucosa, and shown that the amount of ultra-short telomeres is increased in the same situation.
Finally, although with a limited incidence compared to UC, neoplastic degeneration may occur in longstanding CD, so that cross-sectional imaging studies should be scrutinised for features suggesting the possibility of an underlying CRC [13, 32].
This is in agreement with our earlier study showing more intense staining of this HSPG in synovial endothelial cells of longstanding RA compared to normal.
When the indication for the examination was pain, there was a low proportion of positive findings in subjects with longstanding CWP, compared to all others (5.3% vs 28.9%; p = 0.045).
