Exact(17)
SIRT1 expression levels have been reported to be higher in mouse embryonic stem cells (mESCs) as compared to the differentiated cells (Saunders et al., 2010).
The pCSCs are much more potent in tumor neo-vascularization compared to the differentiated tumor monocytic cells (TMCs) derived from the same tumor.
Intensified fluorescence in the IPSC cultures relative to input cells and redifferentiated TER cells suggested that telomeres in pluripotent IPSCs were significantly elongated compared to the differentiated cell types.
In addition, isolated ovarian cancer stem cells exhibit much higher Bmi-1 levels compared to the differentiated or parental bulk tumor cells and have increased resistance to cisplatin and paclitaxel when compared to the tumor cells [23].
A volcano plot revealed a large number of probe sets significantly (p<0.01) overexpressed (basal/differentiated epithelium ratio >5) or underexpressed (basal/differentiated epithelium ratio <0.2) in the basal cells compared to the differentiated epithelium (Figure 2C).
Among extracellular matrix components, 5 laminin subunits corresponding to the α, β1, β3, γ1 and γ2 chains as well as 3 subunits of type IV collagen were overexpressed from 12 to 35-fold in the basal cell signature compared to the differentiated epithelium (Table 5).
Similar(43)
This may be reflected in the higher motility implied by the analysis of the poorly differentiated carcinoma compared to the highly differentiated papillary adenocarcinoma.
Stronger and homogeneous expression of CTIP2 was observed in moderately and/or poorly differentiated tumors (Figs. 1E H) compared to the well differentiated tumors.
The results of the current study suggest that lower glycogen concentrations are found in poorly differentiated cell lines (DU145 and PC3) compared to the better differentiated cell lines (MDApca2b and LnCaP).
Compared to the poorly differentiated tumors (n = 12), well- or intermediate-differentiated tumors (n = 129) significantly correlated with strong STAT1 immunostaining (p = 0.032, Fisher square).
After 8 days of TPA treatment, the level of PGHS-1 enzymes increased in all three cell populations and the platelet fraction, which represents the latest stage of differentiation, contained the greatest amount of enzyme compared to the less differentiated cells found in the non adherent fraction.
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