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Baseline and on-treatment absolute number of lymphocytes and lymphocyte subsets defined by flow cytometry were examined and compared to responding (PR) and non-responding (SD+PD) patients.
Moreover, none of them was studied on refractory patients compared to responding patients.
Indeed, patients who were refractory to treatment showed a significant higher count of TiA1+ cells in the samples studied compared to responding cHL (p = 0.0005).
Moreover, in patients receiving cisplatin FU chemotherapy, we previously supplied direct evidence of the role of intratumoral CH2FH4 on FU efficacy, with significantly lower tumoral CH2FH4 concentrations in nonresponding patients as compared to responding patients (Chéradame et al, 1997b).
Recently, our group found that a microRNA, miR-155, was expressed at high levels in B-cells from patients with CLL compared with B-cells from normal individuals and in plasma of patients who failed to achieve a complete response compared to responding patients, suggesting its role as a biomarker for risk of progression (Ferrajoli et al., 2013).
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Pre-treatment levels of PGC-1 α mRNA were higher in tumours not responding compared to those responding to therapy (borderline significance; P=0.012).
He found that while the rate of correct rejections decreased significantly if one of these confederates gave an incorrect response (as compared to both responding correctly), there was no further difference when both confederates responded incorrectly (as compared to when their opinion was divided).
Others have shown that patients that do not respond to SSG-treatment, have a higher parasite load before treatment compared to patients responding well to SSG [38]; a superior capacity of SSG-resistant strains to establish in vivo infection could be one of the underlying mechanisms of this observation.
They found that both cell lines responded to therapy with HTh7 exhibiting a much higher sensitivity when compared to known responding lymphoma cell lines.
The non-responding group showed significantly higher levels of TYMS expression as compared to the responding group.
For this analysis, patients with responses of 'often' and 'very often' were combined and compared to patients responding with 'always'always
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