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The relative worsening of macular edema at month 6, when compared to month 3, could be explained by the longer interval between treatments and measuring of the macular thickness at month 6, when compared to month 3, which implies that a higher dose and/or more frequent injections of sirolimus may be necessary to achieve and maintain satisfactory outcomes.
Follow-up results showed a significantly larger population reaching control at 6 month 67.522%) as compared to month 1 (44.08%).
However, at month 3, the PRN group showed worsening of mean BCVA compared to month 2. This was not the case in the 3 monthly initial dose group, which showed additional improvement in BCVA after the third injection at month 2. Worsening of mean BCVA was also noted in the 3 monthly initial dose group at month 5.
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