These trends were observed both in the experiments and model predictions, and the higher ability of n-butanol to form soot precursors compared to DEE indeed results mainly from the differences in the fuel structure.
A 3% increase in absolute risk of pancreatic cancer, observed in BRCA2 mutation carriers, from 1 to 4%, is quite significant, while a 3% increase in relative risk for pancreatic cancer due to a common SNP (relative risk 1.03 compared to 1.0) indeed seems negligible.
Disorder, which is encoded by a much wider portion of sequence space as compared to order, can indeed represent a strategy by which genes encoding overlapping reading frames can lessen evolutionary constraints imposed on their sequence by the overlap, allowing the encoded overlapping protein products to sample a wider sequence space without losing function.
As is clearly seen in the traces in Figure 2A, the slight structural modification in 9 compared to 10 does indeed impact hCav3.2 channel inhibition.
4) The authors should determine to which extent the oncogenic fusion is (or is not) overexpressed compared to endogenous Nup98 (indeed, unlike in these ES cells lines, the oncogenic fusions are expressed under the endogenous Nup98 promoter in leukemic cells).
48 This would lower the observed hardening rates in compression as compared to tension, and indeed no pronounced slip steps are observed at low plastic strain during tensile testing.
siControl and siSETD2 cells can be compared to see if indeed depletion of SETD2 affects the p53-dependent checkpoint at the level of the cell cycle as reported by the authors.
However, our data from the Δ399-E402Q mutant compared to Δ399 (and indeed the triple cluster mutant with and without E402Q) provide evidence against any such role for this residue.
We do not consistently see larger suppression of firing following cone stimulation compared to rod stimulation (indeed both rod and cone responses of Figure 1B show clear suppression, with the suppression of firing following rod stimulation lasting considerably longer than that following cone stimulation).
Indeed, compared to past Big Brother casts they are all reasonably normal.
