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Markov models require structural model changes each time they are used, they are comparatively complex (especially when compared to conditional models) and there are no examples in the papers found of Markov approaches incorporating variations in study centre recruitment.
These values were compared to conditional probabilities calculated from reactivity ratios, conversions and monomer feed compositions.
The applied focus of the paper adopts a Bayesian strategy and uses a quantile regression approach that has, as one aspect, the benefit of robustness compared to conditional mean regression, which is demonstrated using simulated data.
In this paper, we found that constitutive exons have higher conservation level in exon regions and lower conservation level in flanking intron regions compared to conditional exons.
Although compared to conditional logistic regression fewer studies and lower patient numbers could be included in these analyses, similar results, which were statistically significant, were obtained (Figure S1).
Lamination quantification of mutant mice at P0 (Gsk3 loxp :Neurod6, Gsk3:Dlx5/6, Ctnnb1 Ex3 :NeuroDvl123 Neurod6rod6, Stk11 Neurod6, Cdc42 Neurod6, Pten:Neurod6) was conducted using heterozygous controls (Cre+, loxP/+) compared to conditional knockouts.
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Though the results seem to indicate the tendency for a higher incidence of miRNAs in fragile sites when compared to genes (conditional and unconditional Fragile IRRmiRNAs > Fragile IRRgenes), the difference is not statistically significant (p>0.05).
Model I provided a better fit to the data compared to the conditional independence model, which is indicated by its much lower deviance = 2974.3.
Our analysis of E14.5 expression data yielded 41 candidate genes that are up-regulated in the control kidneys compared to the conditional mutants.
As compared to the conditional estimator, Koyama Chen estimator had similar bias and lower RMSE under H1, but much higher bias under H0.
A total of 465 genes showed a more than 2 fold increase in expression in the control kidney compared to the conditional mutant kidney (Table 1 and Additional file 4).
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