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This might lead to a substantial underestimation of the true screening effect compared to a screening programme following approved guidelines (in which participants undergo approximately 10 complete rounds in 20 years) [ 41 ].
We advice to follow risk factor guided mutation screening, since these schemes were shown to have a high c-statistic for detection of germline mutations and costs can be reduced up till 40% as compared to a screening in predefined order (SDHB > VHL > RET > SDHD) in each patient presenting with a catecholamine-secreting tumour.
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Specifically, our experiments have demonstrated the significant superiority of the best of the methods – referred to here as SUM-OKA -for screening a range of types of activity class when compared to a conventional screening system based on the Tanimoto coefficient.
Another limitation is that our study does not allow for exploration of differences between experiences of receiving a screening-detected CD diagnosis in a research study compared to a general screening program or being diagnosed due to symptoms.
The event could be more easily compared to a modern screening of The Rocky Horror Picture Show, with the audience heckling, booing, and laughing explosively at the characters on the screen - yet always with a timed and loving reverence.
It should be remembered that there is a large element of extrapolation in applying these results based on relatively poor quality specimens from 1966-82 as compared to a modern screening service.
Compared to a previous screening procedure that utilized the wild type Ls-AChBP crystal structure, the current study shows that the recently obtained α7/Ls-AChBP chimeric protein crystal structure is a better template for the identification of novel α7 receptor ligands.
Even though physicians and nurses may feel confident in their ability to diagnose delirium, using clinical judgment for diagnosis of delirium misses 70% of delirium compared to a standardized screening tool such as the Confusion Assessment Method for the ICU (CAM-ICU) [ 18].
Virtually screening the active DRD2 model predicted only two weak agonists, as well as an inverse-agonist (Table 2, Figure 4); hit rates and potencies were far lower when compared to the screen of the active β2AR structure and as compared to a similar screen of an inactive DRD3 model templated on the inactive β2AR structure.
That gives developers quite a bit more flexibility compared to a traditional screen share.
Compared to a virtual screen, which assumes that actives are more similar to each other than to inactives, the new benchmarks are based upon different assumptions: namely, that within an assay molecules with similar activity tend to have similar structures, and that structural similarity decreases as one moves from one paper to another through molecules in common between both.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com