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This episode was analysed and compared to a previous trial during which no incident occurred.
Other limitations include the small sample size of the study leading to insufficient power, and the relatively short follow-up period compared to a previous trial [ 36] so that the results can only be generalised within 12 weeks.
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Mortality rates were all higher in the HES arm, and 90-day mortality rates were remarkably similar compared to a previous sepsis trial with 10% HES 200/0.5 [ 3].
8 Compared to a previous local randomized controlled trial (RCT) which examined the effectiveness of nursing home visits driven by a protocol which used the Omaha scheme and the standard community nursing service, 18 our subjects were older and frailer, and they had to be taken care of, which means that they are expected to be at a higher risk of emergency hospitalization.
A dissimilar-task-switch occurred when participants had to apply a rule from a different category compared to the previous trial.
A dissimilar-task-switch occurred when participants had to apply a task from a different category compared to the previous trial.
We used a proportion of patients reporting the absence of dyspeptic symptoms as a primary outcome, in order to reach a more reliable conclusion as compared to our previous trial.
The baseline Hcy plasma levels of the treatment group was lower in the current trial (9.4 μmol/l) compared to the previous trial, this is most likely due to the higher level of baseline folate levels in the current trial (35.6 nmol/l) compared to the previous trial (31.4 nmol/l), which displays a possible floor effect.
Recently, results of a Phase I/II study evaluating the effect of a combination of Oblimersen, Temozolomide, and Abraxane on patients with advanced melanoma (NCT00518895) showed increased overall survival as compared to the previous trial.
BALB/c mice showed an increased number of board entries (Fig. 6B) and line crossings in the first reversal trial when compared to the previous trial (Us = −3.604 and −3.759, respectively; ps <.0025), suggesting that the BALB/c mice increased their overall activity level during the first reversal trial, although no effects were found in the other three reversal trials.
So in this experiment, the rate of defected data was doubled in CM1 to identify whether any of the classifiers shows any distinctive changes in results compared to the previous trials; this experiment uses 21 method-level metrics to answer the research question 6.
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