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18– 20, 32– 38, 38, 50 One study compared IDeg to biphasic IAsp 30 (BIAsp 30), 41, 49, 51 and one study compared flexible dosing versus once daily dosing of IDeg.
A shorter 12-week open-label trial (Wilkinson et al 2002) compared flexible doses of donepezil (5 10 mg/day) with flexible doses of rivastigmine (6 12 mg/day) in 111 patients with mild to moderate dementia and found no statistically significant differences in cognition (ADAS-cog mean change −0.9 vs. −1.1, respectively; P > 0.05) at 12 weeks (Wilkinson et al 2002).
The strongest evidence comes from a good-quality 2-year double-blinded randomized trial (Bullock et al 2005) that compared flexible doses of donepezil (5 10 mg/day) with flexible doses of rivastigmine (3 12 mg/day) in 994 participants with moderate to moderately-severe dementia.
In contrast, a shorter 12-week trial compared flexible doses of donepezil 5 10 mg/day (once daily) and galantamine 8 24 mg/day (twice daily) in 120 patients with mild to moderate dementia (Jones et al 2004) and found statistically significant differences in cognition (ADAS-cog mean change −4.7 vs. −2.3, respectively) and function (DAD mean change 1.6 vs. −0.4), favoring donepezil (P < 0.05).
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Another limitation is the lack of a control group as it was intended only to directly compare flexible and rigid belts.
Therefore, concerning response, the results of this network meta-analysis are in conflict with the conclusions of the only clinical trial directly comparing flexible doses of both drugs [ 16].
The morphology of viscoelastic polyurethane (PU) foams is examined and compared with flexible, elastic PU foam.
Late radiation proctitis may be less easy to grade accurately on rigid sigmoidoscopy compared to flexible sigmoidoscopy and there is also anecdotal evidence that some of the bowel preparations commonly used for flexible endoscopic examinations may exacerbate the changes seen.
It is also seen that the base moment is maximum in chimneys with fixed base as compared to flexible base.
Among various flexible energy storage devices, supercapacitors (SCs), also named electrochemical capacitors (ECs), have gain ample attention, as they can provide an instantaneous higher power density, fast charging, long life cycles when compared to flexible batteries [6].
It was also noted that stiffer systems saw the damping ratio increase at a slower rate when compared to flexible systems as the conveyed fluid velocity was increased.
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