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Only patients with an available response rate at the compared end points were analyzed, and if the information was missing, the patient was excluded from the statistical analysis at the corresponding end point.
We compared end points for the IC and IS groups in three patterns: (1) comparison using all the patients in the cohort (n = 76), (2) comparison among cN0 1 patients (n = 52), and (3) comparison of a selected cohort in which IC patients were individually matched with IS patients by PS in all the patients (n = 32), and cN0 1 patients (n = 24).
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To provide a basis for comparing end points with such diversity in the population profile, we calculated mortality rates and disability-adjusted life years (DALYs) lost for end points related to these two risk factors.
A two-tailed (α = 0.05) paired Student t test or Wilcoxon signed rank test (as warranted) were used to compare end points based on the two-period, two-treatment crossover design in 10 patients.
We compared the end points relevant to breast cancer etiology (Table 1) with those included in chemical screening programs under development by the NTP and U.S. EPA to assess how comprehensively those programs evaluate changes in biological processes relevant to breast cancer.
Appropriate parametric or non-parametric techniques will be used to compare secondary end points.
Table 4 combines key pharmacokinetic results from the two Papua New Guinea studies, comparing selected end points for chloroquine [ 112] and azithromycin [ 97].
We did compare our end points with the diagnoses in the cancer register (we had data available for 1998 2006 from this latter register) and found a concordance rate exceeding 90%.
Most studies were retrospective analyses, with a mix of diverse endometrial cancer stages, comparing dissimilar end points (e.g. number of lymph nodes per patient or per lymph node area, or per region of interest), using different treatment strategies, or performing lymphadenectomy to different levels of extent.
In light of recent published studies reporting on cardiovascular outcomes in patients with type 2 diabetes (21, 22), it is important to note that this study was not designed to compare these end point measures (e.g., no stratified randomization based on cardiovascular risk factors, no data collection of past medical history or concomitant nondiabetes medications, and no adjudication of events).
The assessment of early fetal losses (EFLs) in relationship to environmental agents offers unique advantages compared to other end points for hazard assessment.
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