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The tumor samples were grouped by Huvos grade into those with favorable response to chemotherapy (Grades I and II) and unfavorable response (Grades III and IV); and were compared either as a group to normal human osteoblasts (i.e. tumor vs. normal), or to each other (i.e. unfavorable vs. favorable).
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Smaller tumors were formed when FaDu tumor cells were co-injected with MT1-MMP deficient fibroblasts as compared either MMP-2 null (80% smaller) or MMP-9 null (80% smaller) or WT fibroblasts (92% smaller).
Conversely, higher levels of H2O2 were detected in DFs from LLI, as compared either to Young or Old subjects (Fig. 2H); the analysis of median fluorescence intensities indicated that this difference was statistically significant (p<0.05).
Comparing either glucose or ethanol as sole carbon source, ethanol alone resulted in a ~3 times higher PHB yield when the chemostat was operated at D = 0.05 h-1 although it led to a lower biomass yield on substrate.
Treatment of MTOR siRNA-transfected cells with IFNA2c had an additive effect on growth inhibition when compared with either as a single treatment, supporting a role of MTOR in cell proliferation (Table 2).
Treatment of mice with a combination of As-ODN and ATRA resulted in a significant enhancement of the reduction in tumor growth when compared with therapy with either As-ODN (P < 0.01) or ATRA alone (P < 0.01).
Preclinical studies have demonstrated enhanced antitumor activity and inhibition of survivin in HER-2 overexpressing breast cancer cell lines in response to combined trastuzumab and lapatinib therapy as compared with either agent as monotherapy [ 60].
Under field conditions, these formulations increased the grain yield as well as ear parameters as compared with either C. vulgaris extracts or Trichoderma spp. alone as well as non-treated control.
CDF treatment in combination with gemcitabine significantly inhibited tumor growth in MIAPaCa-2 tumors much more than curcumin and gemcitabine combination (Figure 7A) as well as compared to either untreated controls or those treated with a single drug.
Indeed the administration, legal and accounting costs would be relatively high compared to either commencing as a sole trader or, if there is commercial risk, as a simple limited company.
Combination therapy with OLM and AML has been shown to provide increased BP-lowering capabilities compared with either agent as monotherapy [ 9, 10].
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