Exact(2)
To test these hypotheses, we scanned the genome with multiple population genetic statistics and then compared divergent regions to the rest of the genome.
To test this possibility, we scanned the genome using Patterson's D (Durand et al., 2011), a measure of shared ancestry, and then compared divergent regions to the rest of the genome.
Similar(58)
Some methods compare divergent, aligned proteins to spot discriminating residues that suggest functional signatures in sequences (EFICAz2) [20] or in structures (FLORA) [23].
These animals thus provide excellent conditions for studying the epigenetics of senescence by comparing divergent longevities within the same genotypes without the inescapable short-comings of inter-species comparisons.
However, comparing divergent distance with the inner branch length in the phylogenetic tree of leptin, we found the pika branch (shown as branch B in Figure 2A) to be significantly longer than any of the other lineage branches, implying that the variation of leptin sequence in the pika lineage is great.
We blasted the contigs against the zebrafish genome using parameters suitable for comparing divergent sequences.
The problems associated with using bioinformatic methods to compare divergent sequences have been discussed before [ 19].
Furthermore, by comparing divergent bHLH repertoires, we conclude that regulation by Myc but not by other bHLH genes is responsible for the evolutionary maintenance of E CG) sites across the RiBi suite of genes.
We used blast parameter values suitable for comparing divergent sequences (word size = 7; match score = +1; mismatch score = -1; initial penalty for opening a gap = 1; penalty for extending a gap = 2).
Differences in recombination levels could, in principle, account for some of the differences (for instance the very different synonymous variability levels observed at the Solanaceae and Rosaceae S-RNase gene, or the different number and location of positively selected amino acid sites) observed when comparing divergent species groups.
The phenomenon is more prominent in convergent and tandem loci compared to divergent gene pairs (Figure 4C and data not shown).
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