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In order to establish causality, further research would first be required to compare trial reporting with actual trial conduct and then to compare these findings across locations.
Two groups of non-commercial multicentre RCTs were identified to compare trial delivery before and after NCRN was established.
We will extract whether clinically relevant outcomes are reported and compare trial protocols with subsequent publications when available.
Consequently, it is still difficult to compare trial results and to combine them in a meta-analysis.
An ongoing Cochrane review has identified studies that compare trial protocols with subsequent publications (K Dwan, personal communication, 2010).
17 The COMPARE trial examined the effects of GPi versus STN DBS on cognition and mood in 45 patients with a mean PD duration of 13 years.
Similar(50)
The standardised mean difference (SMD) would be used to compare trials that measured the same outcome (construct), but used different scales.
However, these trials are conducted with different protocols, including use of different stem cell populations and different injection protocols, providing little means to compare trials and guide therapy.
In a sub-study, we will compare trials that were discontinued due to insufficient recruitment with completed trials.
Our secondary aim was to characterize and compare trials performed in high- and non-high-income countries.
Given the other non-standardized measures of efficacy used, it is difficult to evaluate and compare trials precisely.
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CEO of Professional Science Editing for Scientists @ prosciediting.com