Sentence examples for comparator trial from inspiring English sources

The more recent 'ATTEST' study (Abatacept or infliximab versus placebo, a Trial for Tolerability, Efficacy and Safety in Treating RA) was a comparator trial that compared abatacept (n = 156), infliximab (n = 165), and placebo (n = 110; plus background methotrexate) in a 1-year efficacy and safety trial conducted in 431 patients with RA who had previously failed methotrexate (≥ 15 mg/week) [ 28].

Third, the estimated RR of achieving NEDA status for fingolimod versus placebo in the pooled FREEDOMS population (from the 'estimated' models) and the predicted RRs for fingolimod versus placebo in comparator trial populations (from the 'predicted' models) were compared with those calculated for DMF and teriflunomide in their respective trials.

In the first comparator trial of two biologic agents, ustekinumab showed superiority compared with etanercept in the treatment of moderate to severe plaque psoriasis.

This study will provide the greatest possible insight into whether DPP-4 inhibitors hold advantages over SUs in terms of CV outcomes, and despite other ongoing comparative effectiveness studies, like GRADE, CAROLINA is the only active-controlled comparator trial sufficiently powered to address CV outcomes.

This 52-week Canagliflozin Treatment and Trial Analysis dipeptidyl peptidase-4 inhibitor (CANTATA-D2; second comparator trial) study evaluated the efficacy and safety of canagliflozin 300 mg compared with sitagliptin 100 mg as add-on therapy in subjects with type 2 diabetes inadequately controlled with metformin plus a sulfonylurea agent.

weeks of double-blind treatment with sertraline in flexible daily doses in the range of 50 - 150 mg (in the nortriptyline comparator trial) or 50 - 100 mg (in the fluoxetine comparator trial).

Sneed et al. [ 23] also found higher response rates in patients in comparator trials (60% response) compared with placebo-controlled trials (46% response).

Most of the eligible trials included active comparators: there were 80 two-armed placebo controlled trials as compared to 103 two-armed or multi-armed active comparator trials (see table 1 in web appendix).

The alternative to inactive placebo is to compare a new medication with the best current medication, accepting that such comparator trials may produce higher placebo response rates than placebo-controlled trials [ 48].

22 We tested the hypothesis that industry sponsorship bias would occur when a pharmaceutical sponsor favoured its own product in placebo controlled or active comparator trials, or the highest dose of its own drug in a trial comparing multiple doses.

It is also necessary when designing antipsychotic comparator trials which control for dosage.