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The BIGSdb Genome Comparator tool, implemented within the website was employed to compare isolate WGS data.
Assembled draft genome sequences were compared to their reference genome using the BIGSdb Genome Comparator tool and assessed using the finished genome CDS sequence annotation.
The four draft sequences for which finished genome sequences were available (H44/76, FAM18, Z2491, and G2136) were compared to the published closed sequences using the BIGSdb Genome Comparator tool.
The BIGSdb Genome Comparator tool was used to assess genome coverage of the resequenced reference genomes (Table 3a and b).
A core genome of 1600 loci, present in at least 95% of the population, was determined using the Genome Comparator tool.
The Genome Comparator tool was used within BIGSdb [ 31] to perform wgMLST analysis [ 22] using the 1643 genetic loci validated for this form of analysis [ 21].
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Simple correlations using Pearson's test were used to compare the MGI QoL score and those on the comparator tools.
We then compared this analysis with the components of these responses to the comparator tools and with the outcomes identified by Smith et al. [ 3] in their systematic review of outcomes in the Cochrane Pregnancy and Childbirth database.
Data extraction was undertaken based on the CASP quality assessment tool to extract information from included articles in relation to study participants/sample, type of interventions using EASY-Care, comparator tools or standards, assessment outcomes and measurements of reliability, validity and acceptability.
As described in the Methods section we used the T-Reg Comparator [24] tool to compare our motif to all 2203 known motifs included in the T-Reg web site search and to reveal potential (local) likeness.
PICO stands for Population Indication Comparator Outcomes and it is an important tool in evidence-based medicine.
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