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Low dose inhaled corticosteroid treatment was the comparator strategy.
This comparator strategy was not included in the former analyses, showing the dominancy of FIT.
For the "standard care comparator strategy", we assumed that the same proportion of patients would be eligible to undergo revascularization (i.e. PCI, CABG) as those who currently receive catheterization.
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Approximately half of the studies found FIT to be a dominant screening strategy, providing more life-years for lower costs than the comparator strategies.
Because the treatment strategies used were different, countries under analysis were different, and comparator strategies were different, direct comparison of these analyses with the current analysis are difficult (12– 12).
Instead, we used a comparator medication strategy to determine if falls risk differed between classes of medications that are used to treat similar medical conditions.
Previous trials suggesting that high-frequency oscillatory ventilation (HFOV) reduced mortality among adults with the acute respiratory distress syndrome (ARDS) were limited by the use of outdated comparator ventilation strategies and small sample sizes.
Comparator: usual care, no strategy or a different implementation strategy (either single or multifaceted).
For retention trials, we recorded data on the method of randomisation, type of strategy evaluated, comparator, primary outcome, planned sample size, numbers randomised and numbers retained.
Therefore, the 'dominance' of each strategy over comparators should be carefully interpreted.
The authors independently extracted study data including: 1) study objective(s); 2) study setting; 3) study design and population size; 4) incentives provided to supervisors; 5) inclusion and exclusion criteria for different DOT strategies; 6) comparator group(s); 7) study outcomes & results; 8) study limitations; 9) main conclusion(s) and 10) study funding source(s).
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