The previously cited analysis of joint scientific advice meetings [17] showed that in cases where the EMA and HTA bodies did not agree on the comparator, the suggested solution was most frequently an indirect comparison.
The proposed algorithms with a polygonal operating characteristic are based on a time-domain phase comparator and compared to an algorithm based on discrete Fourier transformation (DFT), which is considered as a classical solution in this area.
Dexamethasone was chosen as the comparator corticosteroid as visually the solution is similar to Tr14 injection solution, thus aiding blinding of those administering the injections.
The much higher than standard (typically 0.5 2.0 μg/mL) enzyme concentrations employed in this solution-phase comparator reaction were utilized to better reflect the high local concentration of the immobilized system (estimated as 3 g/mL as previously described).
During the sKATP channel characterization phase of this study (see series 1), pipette solutions containing KCl 70 mM NaCl 70 mM (NaCl, 70 mM equimolar substitution) and KCl 200 mM were used as comparator to the standard pipette solution.
Appropriate dilutions of novel tetracyclines and comparator compounds (20-mg/ml stock solutions in dimethyl sulfoxide [DMSO]) were made in cation-adjusted Mueller-Hinton broth (BBL) using the Tecan robotic workstation, followed by inoculation.
However, this is the robust way to study whether there is an evidence that regenerative tissue engineering solutions can be favoured over comparator treatments for targeted clinical conditions or not.
In order to achieve this, we propose a DNA-based algorithm of an n-bit parallel adder and a DNA-based algorithm of an n-bit parallel comparator to formally verify our designed molecular solutions for the subset-sum problem.
In order to achieve this, we propose three DNA-based algorithms – parallel adder, parallel multiplier and parallel comparator – that formally verify our designed molecular solutions for the subset-product problem.
Through the combination of a modified architecture and comparator interpolation this high quantizer resolution is achieved with only 15 comparators.
