However, Klein et al. [ 15, 30] do not undertake a full incremental analysis between all available comparators (Question 6).
Background characteristics included the following: title, author/s, year, journal, intervention and comparators, objective/study question, target audience, economic study type, study population, setting and country; and source of funding/conflict of interest.
Therefore, given the fact that this study included a majority of patients with platinum-sensitive disease, the validity of the comparator may be questioned.
PICO (Population, Intervention, Comparator, Outcome) formatted questions (Table 2) were thus constrained from the outset by a modest set of opinions from those within the GRADE-team and local observations.
A Population, Interventions, Comparators, Outcomes, Study (PICOS) question design was used to guide the development of the review question [ 29].
The new assessment instrument was tested by a group of potential users who determined it to be helpful in evaluating RCTs to aid in answering a clinical question, as compared to a published comparator instrument.
23 24 The study aims were structured in a systematic way, using the elements of a clinical research question (population, intervention, comparator and outcome/PICO).
This advertisement includes a commissioning brief that gives details relating to the research question, participants, intervention, comparator, and outcome measures, as well as the suggested study type.
We examined whether the reports stated each of the five elements of a structured research question: population, intervention, comparator, outcome and time-frame.
We excluded eight questions that did not present a minimum of two PICO components (population, intervention, comparator or outcome) and one diagnostic question.
