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To confirm the greater sensitivity of the cobas EGFR test compared to Sanger, a third comparator method was used, MPP.
Alternative static experimental methods include the temperature oscillation method [16, 17, 28], micro-hot-strip method [29], steady-state cut-bar method [30], 3-ω method [18, 31, 32], radial heat-flow method [33], photo-thermal radiometry method [34], and thermal comparator method [19, 35].
The second comparator method was a fluorescent dye-binding assay (Qubit).
Quantification of all element mass fractions was based on the single comparator method [ 10].
Finally, we briefly describe the benefits and limitations of H NMR, making reference to MS as a comparator method.
Though we showed that both methods provide similar information on physical activity levels, behavioural mapping is not a perfect gold standard as a comparator method, since it has a low sampling rate.
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Results: Using structurally different NCEs, it was shown that a combination of direct injection via the saphenous vein and multiple sampling from the tail vein produces comparable plasma concentrations and subsequent PK results to the comparator methods.
Of the three comparator methods, posttreatment offered the most robust method of analysis compared with ANCOVA, and the change score and percent change score methods offered the least favorable method in terms of precision and magnitude of effect.
Quantitative analysis was performed on 103 specimens only, as 12 specimens had no percent ratio reported with one of the comparator methods (reported as positive but below the LOQ of the LDT).
The cut off value chosen for confirmatory screening will be dependent on the glucose meter and the comparator reference method.
5 The clinical question as formulated by the experts was translated into an epidemiological research question according to the PICO (patient, intervention, comparator, outcome) method.
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