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In conclusion, external observational data provide useful information when long-term comparator data from randomised controlled trials are not available.
The lack of comparator data from across Africa makes it impossible to conclude whether the pyrethroid resistance levels seen in Burkina Faso are atypical.
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Sensitivity of the results to the deletion of these isolates is presented in Additional file 5. Comparator data for the regression analysis was gathered from GenBank on 5th July 2013.
We calculated risk ratios for US studies relative to separate comparator data obtained from the Centers for Disease Control and Prevention's vital statistics 2006 (US national statistics) for pooled incidences and for individual study outcomes.
In contrast, the perturbation score we applied in the present study is independent of comparator data.
In the absence of a comparator group, reference data from phase III trial data and published literature can aid in interpreting program impact as well by providing an a priori threshold for program success [ 11, 64].
Firstly, this study is a quality improvement initiative rather than a randomized controlled trial, with no comparator group or clinical data from the period prior to the intervention.
The relationship between proportion of diabetic patients at inclusion and PO or CHD rates was inferred on the basis of the comparator and treatment arms data from the 33 predominantly non-diabetic studies, including where appropriate the rates for the corresponding DSS, ie 259,151 patients.
While such assays might not be suitable for the rapid combined analyses described, the results from rat brain tissue can serve as a physiologically relevant comparator for data obtained from transfected cells expressing DAT, NET, or SERT.
Second, we can talk to the drug companies at their shareholder meetings and ask them to be a leading examples by sharing data from the comparator arms of their trials.
At each footprint locus the data from the comparator dataset is added and the Wellington footprint score for the pooled data evaluated.
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