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However, limited head-to-head comparator data were available within the tofacitinib RA development program to directly compare rates of serious infections with tofacitinib relative to biologic agents, and specifically adalimumab (employed as an active control agent in two randomized controlled trials of tofacitinib).
In contrast, the perturbation score we applied in the present study is independent of comparator data.
These variations are similarly found in the other major comparator data sets.
Treatment and comparator data, as well as relevant epidemiological parameters for the technology, are valid in the new context.
In conclusion, external observational data provide useful information when long-term comparator data from randomised controlled trials are not available.
Numbers under the line refer to the number of studies for the direct comparator data, whereas numbers above the line indicate pooled RRs.
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To our knowledge this is the only comparator data-set in existence comparing suicide-related events between these two common treatments for ADHD.
injection of the carprofen comparator groups (data not shown).
As a result, even though these hero companies have achieved a "proof of effort," there will be a huge amount of useful valuable clinical trial comparator arm data that remains unshared.
The first cluster of 19 ICUs (15 adult, 4 paediatric) provided baseline comparator infection data for subsequent clusters.
Overall, 26 participants experienced serious adverse CV events: 15 (0.6%) in the exenatide group and 11 (0.7%) in the pooled comparator group (data not shown).
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