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The nature of the comparator (control) group also differs across high-risk studies.
Eighteen studies were found fulfilling search criteria; six were excluded due to duplicate publication, active comparator control or open design.
It is also the only study on pH1N1 vaccine in HIV-infected patients that included a comparator control group.
Online as the comparator (control) group.
Use of an active comparator control condition.
Only one trial specified a theoretical approach underpinning the comparator control intervention.
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It has been shown that amelogenin can significantly reduce ulcer size and also significantly increase the number of patients showing a greater than 50% reduction in wound size, compared with comparator controls.
Pain is a problem in patients with VLUs, but it has been shown that amelogenin therapy can reduce the level of pain experienced by patients with hard-to-heal VLUs, compared with comparator controls.
Over the 46-week active comparator controlled period, etoricoxib 30, 60, and 90 mg had similar efficacy compared with diclofenac 150 mg.
I did not include many double-blind non-inferiority active comparator controlled studies, if efficacy of "active control" was not proven, e.g., [29, 30].
Table 1 Short description of clinical studies with Cimiciduga racemosa preparations Ref. (placebo or comparator controlled) Design Patient characteristics and age Treatment, dose, and duration Outcome measures Finding and comments Effects in short No = Ø Signif.
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