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Here, we have used an unbiased approach to comparatively map genome-wide interactions of gene promoters with lamin A and progerin, the mutated lamin A isoform responsible for the premature aging disorder Hutchinson Gilford progeria syndrome (HGPS) in mouse cardiac myoytes and embryonic fibroblasts.
For example, although we could detect Artemis nuclease in our FLAG-DNA-PKcs IPs, the overall yield of Artemis was comparatively low, thereby making it technically challenging to discover Artemis in an unbiased fashion among other proteins of low abundance present in the complex.
Lake is hardly unbiased.
"We're unbiased".
Comparatively well.
Scientists should be unbiased.
Many are comparatively shallow.
Manhattan seems comparatively underserved.
"We must remain unbiased.
An unbiased stereological study.
Uninterrupted, yes, but not unbiased.
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