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A comparison of the landscape of non-coding conservation in the human and D. melanogaster genomes (Figure 2) suggests an explanation for the differential effectiveness of comparative regulatory sequence identification in these two species.
Finally, the comparative regulatory region analysis allowed the identification of a conserved region, where many TFs, annotated to participate in pancreas formation, bind and regulate Wnt5 expression.
As a result, there is a need for easy-to-use web integrative resources that perform comparative regulatory analyses on emerging next-generation sequencing data.
Taking into account the importance of Wnt5 genes during development of pancreas, in relation to shifting roles between paralogs, we decided to conduct a phylogenetic and an in silico comparative regulatory region analysis of Wnt5 genes.
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Several approaches have been developed to overcome the lack of comparative information on regulatory interactions that is necessary in works aimed at studying the evolution of regulatory networks.
This study investigated the resulting workload in terms of the number of cases for comparative assessments that regulatory authorities may have to face.
Given that New Zealand and Pakistan also have near identical regulations, their foundations both being from British common law, the aim of this study is to conduct a comparative analysis of regulatory and institutional mechanisms that shape CSR disclosures in each jurisdiction.
Comparative analysis of regulatory regions revealed the presence of common guard cell-specific motifs in the promoters of the grape and Arabidopsis MYB60 genes.
As a final remark, we suggest that an in silico comparative analysis of regulatory regions, especially when associated to published experimental data, represents a powerful approach for explaining shift of roles among paralogs.
In addition, eventually comparative research on regulatory genes may become also helpful for deep phylogenetic studies and might bridge some gaps between description and causal explanations (Hadrys et al. 2012).
Comparative analysis of modular regulatory sequences of various species is a powerful approach for pinpointing functionally relevant regulatory elements [ 31- 33].
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