We review the evolution of autologous chondrocyte implantation, comparing it to the aforementioned cartilage repair techniques, discuss relevant comparative clinical trials, and briefly highlight some emerging new strategies for chondral repair.
So I went to the medical literature to read comparative clinical trials and was astonished to find only a handful, the best of which was from Sweden.
It will also work on a way for companies to easily procure one another's already marketed drugs for use in comparative clinical trials.
Its cost-effectiveness and usefulness for the management of critically ill patients remains to be proved in prospective comparative clinical trials [30].
These approaches are methodologically complex but advancement in software packages had made the planning, monitoring, and analysis of comparative clinical trials according to these approaches quite simple.
The carbapenems are widely regarded as the drugs of choice for the treatment of severe infections caused by ESBL-producing Enterobacteriaceae, although comparative clinical trials are scarce.
New strategies combining new chemotherapy protocols or targeted therapy with radiation are promising but have to be evaluated in comparative clinical trials before use in routine.
For five of the seven products, well-controlled comparative clinical trials were conducted as pre-approval evaluation followed by post-approval evaluation.
Fundamental to the successful implementation of antifungal compounds in neutropenic patients is the appropriate design of comparative clinical trials investigating their safety and efficacy.
This raises several issues such as the design of comparative clinical trials and the occurrence of partial efficacy which is considered a risk factor for the development of anthelmintic resistance.
The concept of "incremental" evolution and the dosimetric evidence are proposed as an acceptable alternative to comparative clinical trials if total dose, time, fractionation, and target volumes are not modified.
